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Explore a Potential Treatment Option for Social Anxiety


A research study is evaluating a potential new treatment for Social Anxiety Disorder (SAD).

If you or someone you know experiences fear, avoiding people or feeling nervous around others, you may qualify to participate in The AFFIRM-1 Study.
SEE IF YOU QUALIFY
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Explore a Potential Treatment Option for Social Anxiety


A research study is evaluating a potential new treatment for Social Anxiety Disorder (SAD).

If you or someone you know experiences fear, avoiding people or feeling nervous around others, you may qualify to participate in The AFFIRM-1 Study.
SEE IF YOU QUALIFY

About The AFFIRM-1 Study

Social Anxiety Disorder (SAD), also known as social phobia, affects millions of people in the United States. Symptoms can include feeling sick to your stomach, a fast heartbeat, lots of sweating, shaking, trouble talking, feeling dizzy, and being really scared of what others think or being embarrassed around people.

These symptoms can interfere with daily life, making work, school, and relationships challenging.

While some treatments may help, there is currently no universally effective solution for SAD. That's why researchers in The AFFIRM-1 Study are investigating a potential treatment option for symptoms of social anxiety disorder.



LEARN MORE

Who can participate in The AFFIRM-1 Study?

You may be able to participate in The AFFIRM-1 Study research study if you:

  • Are between 18 to 65 years old
  • Experiencing symptoms of social anxiety or have a diagnosis of Social Anxiety Disorder (SAD)
  • Other criteria apply



SEE IF YOU QUALIFY TODAY

Pre-Qualifying Questionnaire


To see if you may qualify for this research study, please complete this Pre-Qualifying Questionnaire.

By clicking to begin the pre-qualifying process, you allow us to proceed with the pre-qualifying questions and to begin recording your answers. By clicking you also agree to the terms of the Privacy Policy.

If pre-qualified, please enter your name and contact information. Your name and contact information will not be associated with the questionnaire answers unless you provide this information after you complete the pre-qualifying questionnaire.



1

Are you 18 to 65 years of age?

 Yes   No 

2

How did you hear about this research study?

3

Please enter your home or work zip code. This zip code will be used to locate a study center near you. Please provide the zip code that would be most convenient.

Enter 5-digit zip code

4

Has a health care professional told you that you have social anxiety disorder?

 Yes   No   Unsure 

5

Do you regularly experience anxiety, self-consciousness, or excessive worry when in social situations, being the center of attention or being in front of an audience?

 Yes   No   Unsure 

  Completion Status

Understanding Social Anxiety Disorder (SAD)

According to the National Institute of Mental Health (NIMH), Social Anxiety Disorder (SAD), or social phobia, is a chronic condition that causes intense fear of social or performance situations, especially when feeling judged by others. This fear can lead to distress, avoidance, and difficulty with work, school, and relationships.

Common symptoms of Social Anxiety Disorder (SAD) may include:

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Racing Heart

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Nausea

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Excessive Sweating

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Difficulty Speaking in Social Situations



It often starts in childhood or adolescence, particularly in those who are naturally reserved or anxious in social settings. SAD may become more severe without treatment.

Not just a condition of feeling sad or worried, SAD can affect self-esteem and mental health. However, there are some treatment options, and ongoing research is exploring new ways to help individuals manage symptoms and improve daily life.

Study Locations

See if there is a study location near you.

California
La Jolla
Temecula
Georgia
Decatur
Massachusetts
Boston
New York
Brooklyn
Pennsylvania
Media

What is Clinical Research?

Clinical research is the foundation of medical advancement, helping doctors and scientists develop new ways to prevent, diagnose, and treat illnesses. Through research studies, also known as clinical trials, new medications and treatments are carefully tested to determine their safety and effectiveness before becoming widely available. These studies rely on volunteer participants who help researchers gather important data.

While there is no guarantee of direct benefit for participants, their involvement contributes to medical progress, potentially improving future treatment options for others. By participating in clinical research, individuals play an essential role in shaping the future of healthcare. Every breakthrough in medicine—from vaccines to life-saving treatments—was made possible by clinical trial volunteers.

Learn more about clinical research

Frequently Asked Questions (FAQ’s)

This study is testing a new treatment for Social Anxiety Disorder to see if it can effectively reduce symptoms like fear, avoidance, and physical anxiety.

By participating, you’re helping researchers learn more about Social Anxiety Disorder and how to treat it. Your involvement can lead to better treatments, improved quality of life for others, and new breakthroughs in mental health care.

About 1–3 weeks before the study begins, you'll visit the study center for a Screening Visit. During this visit, you’ll receive a physical exam, including vital signs, lab work, and an electrocardiogram (ECG). Your study doctor will take and review your medical history, confirm your diagnosis of social anxiety disorder (SAD), and discuss how your symptoms impact your daily life to ensure that you qualify for the study.

If you qualify, you’ll return to the study center within 3 weeks for your Treatment Visit. You’ll receive a single dose of either the study drug or a placebo, be asked to take part in a behavioral assessment task, and complete questionnaires about how you’re feeling throughout the treatment day. Some of the same health checks and lab tests from your first visit will also be repeated.

About 1 week later, a follow-up phone or video call will be scheduled to check in on how you’re feeling.

No. All study-related clinic visits, procedures, and the study drug or placebo are at no charge.



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